This article is a reasoned response to the article by Timothy F. Murphy, recently published in the prestigious journal Bioethics, on the supposed opposition between the views of the Catholic Church and what he calls “contemporary science” in relation to certain anthropological issues linked to the gender perspective. To point to “the Vatican” as anchored in an unscientific and anachronistic position, using the term contemporary science to which he attributes a unanimous representation of current scientific thinking on the subject is, in our view, unfounded and completely unacceptable. In his reflection, he does not adequately distinguish between intersex and transgenderism, two clearly different realities with different needs. The author defends the obsolescence of the binary sex/gender model that, in his view, “betrays human sexuality.” Furthermore, he does so without providing a plausible justification or a definition of human nature that is able to support the plurality and indeterminacy of sexual conditions, without falling back on untenable dualisms or relativism devoid of scientific objectivity. In our response, we highlight how the dialogue between Faith and Reason, as developed in the recent Magisterium of the Catholic Church, is essential to explain nature, the human being and, in general, all creations. Finally, contemporary science does not provide a monolithic and unquestionable view of the nature of human beings and their sexual identity, as the author claims, with many scientists confirming evidence of a binary human sexuality genetically and phenotypically determined.